| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | MAP, Merlin-associated protein, RABGAPLP, RUN and TBC1 domain-containing protein 3, RUTBC3, Rab-GTPase-activating protein-like protein, RabGAPLP, SGSM3, Small G protein signaling modulator 3 |
| Immunogen | E. coli - derived recombinant Human SGSM3 (Met1-Gly382). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q96HU1 |
| Background | Small G protein signaling modulator 3 (SGSM3) is a ~85 kDa protein. GTPase-activating protein (GAP) specific for Rab5 small GTPase for which it accelerates the intrinsic GTP hydrolysis rate, thereby controlling trafficking through the early endocytic pathway. May play a cooperative role in NF2-mediated growth suppression of cells. 1. Haas, AK. et al. (2005) Nature cell biology 7, 887-93. PMID: 16086013 2. Fuchs, E. et al. (2007) The Journal of cell biology 177, 1133-43. PMID: 17562788 |
| Note | For research use only |