| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human |
| Target | 39S ribosomal protein L12, mitochondrial; L12mt; MRP-L12; 5c5-2; Mitochondrial large ribosomal subunit protein bL12m; MRPL12; MRPL7; RPML12 |
| Immunogen | E. coli - derived recombinant Human MRPL12 (His129-Glu198). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P52815 |
| Background | Large ribosomal subunit protein bL12m (MRPL12) is a ~21 kDa protein. As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability. 1. Serre, V. et al. (2013) Biochimica et biophysica acta 1832, 1304-12. PMID: 23603806 2. Surovtseva, YV. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 17921-6. PMID: 22003127 3. Nouws, J. et al. (2016) The Journal of biological chemistry 291, 989-97. PMID: 26586915 |
| Note | For research use only |