Anti-Human CHRNA7 Recombinant Nanobody
- Cat. No.：RB9THW806013
- Price：Negotiable
- Clicks：124
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Alpaca |
| Clonality | Monoclonal |
| Isotype | VHH-His |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA |
| Species Reactivity | Homo sapiens (Human) |
| Target | CHRNA7, NACHRA7, Neuronal acetylcholine receptor subunit alpha-7, Nicotinic acetylcholine receptor subunit alpha-7, nAChR7 |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Accession Number | P36544 |
| Background | Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA7 forms homopentameric neuronal acetylcholine receptors abundantly expressed in the central nervous system, characterized by fast desensitization and high calcium permeability. Also forms heteropentamers with CHRNB2, mainly expressed in basal forebrain cholinergic neurons. 1. Ellison, M. et al. (2004) Biochemistry 43, 16019-26. PMID: 15609996 2. Noviello, CM. et al. (2021) Cell 184, 2121-2134.e13. PMID: 33735609 3. Peng, X. et al. (1994) Molecular pharmacology 45, 546-54. PMID: 8145738 4. Nielsen, BE. et al. (2019) Neuropharmacology 160, 107794. PMID: 31560909 5. Burke, SM. et al. (2024) Cell 187, 1160-1176.e21. PMID: 38382524 6. George, AA. et al. (2021) The Journal of neuroscience : the official journal of the Society for Neuroscience 41, 555-575. PMID: 33239400 7. Wang, H. et al. (2003) Nature 421, 384-8. PMID: 12508119 8. Yoshikawa, H. et al. (2006) Clinical and experimental immunology 146, 116-23. PMID: 16968406 |
| Note | For research use only |
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