Anti-G protein/Gαβγ Recombinant Nanobody (Nb35)
- Cat. No.：RB9THX948013
- Price：Negotiable
- Clicks：681
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Alpaca |
| Clonality | Monoclonal |
| Isotype | VHH-His |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | Crystallography, Cryo-EM |
| Species Reactivity | Homo sapiens (Human) |
| Target | Adenylate cyclase-stimulating G alpha protein, EC:3.6.5.-, GNAS, GNAS1, GSP, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short |
| Storage Buffer | 0.01M PBS pH 7.4 |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Accession Number | P63092 |
| Background | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gαβγ) is a ~45 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 2. Gao, X. et al. (2007) The Journal of biological chemistry 282, 294-302. PMID: 17110384 3. Thiele, S. et al. (2011) Human mutation 32, 653-60. PMID: 21488135 4. Brand, CS. et al. (2015) Molecular pharmacology 88, 758-67. PMID: 26206488 5. Farfel, Z. et al. (1996) The Journal of biological chemistry 271, 19653-5. PMID: 8702665 6. Warner, DR. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 4268-72. PMID: 10200251 |
| Note | For research use only |
Related Products:
| Product Name | Clicks |
|---|---|
| 抗口蹄疫病毒非结构蛋白单克隆抗体 | 4870 |
| 抗猪弓形虫单克隆抗体 | 5142 |
| 抗猪肺炎支原体单克隆抗体 | 4590 |
| 抗星状病毒单克隆抗体h | 4912 |
| 抗猪传染性胃肠炎病毒单克隆抗体 | 4872 |
| 抗猪轮状病毒单克隆抗体H | 5079 |
| 抗猪伪狂犬病毒单克隆抗体 | 5235 |
| 抗猪伪狂犬病毒单克隆抗体 | 4858 |
| 抗猪塞内加谷病毒单克隆抗体 | 4885 |
| 抗猪A型流感病毒单克隆抗体 | 4951 |
| 抗猪A型轮状病毒单克隆抗体 | 5378 |
| 抗猪繁殖与呼吸障碍综合征病毒单克隆抗体 | 5410 |
| 抗猪链球菌35个型病毒单克隆抗体 | 5424 |
| 抗非洲猪瘟病毒单克隆抗体 | 4842 |
| 禽支原体单克隆抗体 | 4807 |
| 抗通用型禽流感单克隆抗体 | 5515 |
| 抗新城疫单克隆抗体 | 4888 |
| 抗甲型流感 H5/H7 /H9亚型单克隆抗体H | 5014 |
| 抗传染性支气管炎病毒单克隆抗体H | 4754 |
| 抗传染性法氏囊病毒单克隆抗体H | 5710 |