| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Human, Mouse |
| Target | EH domain-containing protein 3, EHD2, EHD3, PAST homolog 3, PAST3 |
| Immunogen | E. coli - derived recombinant Human EHD3 (Thr20-Ser402). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9NZN3 |
| Background | EH domain-containing protein 3 (EHD3) is a ~60 kDa protein. ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. 1. Lu, Q. et al. (2015) Nature cell biology 17, 228-240. PMID: 25686250 2. Cai, B. et al. (2013) The Journal of biological chemistry 288, 30172-30180. PMID: 24019528 3. Naslavsky, N. et al. (2006) Molecular biology of the cell 17, 163-77. PMID: 16251358 4. George, M. et al. (2007) BMC cell biology 8, 3. PMID: 17233914 5. Naslavsky, N. et al. (2009) Journal of cell science 122, 389-400. PMID: 19139087 6. Waxmonsky, NC. et al. (2013) Journal of cell science 126, 3593-601. PMID: 23781025 7. Kotowski, SJ. et al. (2011) Neuron 71, 278-90. PMID: 21791287 8. Gudmundsson, H. et al. (2010) Circulation research 107, 84-95. PMID: 20489164 |
| Note | For research use only |