| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:2.3.2.27, HDNB1, Homozygously deleted in neuroblastoma 1, KIAA0684, RING-type E3 ubiquitin transferase E4 B, UBE4B, UFD2, Ubiquitin conjugation factor E4 B, Ubiquitin fusion degradation protein 2 |
| Immunogen | E. coli - derived recombinant Human UBE4B (Leu961-His1302). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O95155 |
| Background | Ubiquitin conjugation factor E4 B (UBE4B) is a ~146 kDa protein. Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation. 1. Janiesch, PC. et al. (2007) Nature cell biology 9, 379-90. PMID: 17369820 |
| Note | For research use only |