| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | C1orf107, DEF, DIEXF, Digestive organ expansion factor homolog, U3 small nucleolar RNA-associated protein 25 homolog, UTP25, UTP25 small subunit processor component |
| Immunogen | E. coli - derived recombinant Human UTP25 (Asn180-Asn561). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q68CQ4 |
| Background | U3 small nucleolar RNA-associated protein 25 homolog (UTP25) is a ~87 kDa protein. Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53. 1. Tao, T. et al. (2013) Cell research 23, 620-34. PMID: 23357851 2. Lei, H. et al. (2014) BMC gastroenterology 14, 123. PMID: 25007945 3. Guan, Y. et al. (2016) PLoS biology 14, e1002555. PMID: 27657329 |
| Note | For research use only |