Anti-Human SVIL Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Mouse, Human
Target	Archvillin, SVIL, Supervillin, p205/p250
Immunogen	E. coli - derived recombinant Human SVIL (Met1444-Lys1678).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	O95425
Background	Supervillin (SVIL) is a ~247 kDa protein. Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. 1. Oh, SW. et al. (2003) Journal of cell science 116, 2261-75. PMID: 12711699 2. Crowley, JL. et al. (2009) Molecular biology of the cell 20, 948-62. PMID: 19109420 3. Laurent, B. et al. (2015) Molecular cell 57, 957-970. PMID: 25684206
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

Related Products: