Anti-Human CBX4 Polyclonal Antibody
- Cat. No.：RB9THT334014
- Price：Negotiable
- Clicks：213
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Homo sapiens (Human) |
| Target | CBX4, Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, EC:2.3.2.-, Pc2, Polycomb 2 homolog, hPc2 |
| Immunogen | E. coli - derived recombinant Human CBX4 (Glu2-Gly73&Gly245-Gln275). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O00257 |
| Background | E3 SUMO-protein ligase CBX4 is a ~61 kDa protein. E3 SUMO-protein ligase that catalyzes sumoylation of target proteins by promoting the transfer of SUMO from the E2 enzyme to the substrate. Also acts as a histone reader, which specifically recognizes and binds histone H3 trimethylated at 'Lys-9' and 'Lys-27' (H3K9me3 and H3K27me3, respectively) via its chromo domain. Catalyzes sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Acts as a regulator of brown adipocyte differentiation by mediating sumoylation of PRDM16, thereby preventing PRDM16 ubiquitination and degradation. Monosumoylates ZNF131. 1. Kagey, MH. et al. (2003) Cell 113, 127-37. PMID: 12679040 2. Oh, Y. et al. (2012) The Journal of biological chemistry 287, 17517-17529. PMID: 22467880 3. Pelisch, F. et al. (2012) The Journal of biological chemistry 287, 30789-99. PMID: 22825850 4. Levine, SS. et al. (2002) Molecular and cellular biology 22, 6070-8. PMID: 12167701 5. Maertens, GN. et al. (2009) PloS one 4, e6380. PMID: 19636380 6. Vandamme, J. et al. (2011) Molecular & cellular proteomics : MCP 10, M110.002642. PMID: 21282530 |
| Note | For research use only |
Related Products: