Anti-Human DBR1 Polyclonal Antibody
- Cat. No.：RB9THV163014
- Price：Negotiable
- Clicks：379
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | DBR1, EC:3.1.4.-, Lariat debranching enzyme |
| Immunogen | E. coli - derived recombinant Human DBR1 (Met1-Pro273). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9UK59 |
| Background | Lariat debranching enzyme (DBR1) is a ~61 kDa protein. Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover. Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis and have an antiviral cell-intrinsic defense function in the brainstem. 1. Kim, JW. et al. (2000) Nucleic acids research 28, 3666-73. PMID: 10982890 2. Ye, Y. et al. (2005) Retrovirology 2, 63. PMID: 16232320 3. Arenas, J. et al. (1987) The Journal of biological chemistry 262, 4274-9. PMID: 2435736 4. Zhang, SY. et al. (2018) Cell 172, 952-965.e18. PMID: 29474921 |
| Note | For research use only |
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