Anti-Human MELK Polyclonal Antibody
- Cat. No.：RB9THC349014
- Price：Negotiable
- Clicks：131
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:2.7.10.2, EC:2.7.11.1, KIAA0175, MELK, Maternal embryonic leucine zipper kinase, Protein kinase Eg3, Protein kinase PK38, Tyrosine-protein kinase MELK, hMELK, hPK38, pEg3 kinase |
| Immunogen | E. coli - derived recombinant Human MELK (Met1-Phe337). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q14680 |
| Background | Maternal embryonic leucine zipper kinase (MELK) is a ~74 kDa protein. Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. |
| Note | For research use only |
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