Anti-Mouse F2RL1 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Mus musculus (Mouse)
Target	Proteinase-activated receptor 2; PAR-2; Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1; F2rl1; Gpcr11; Gpr11; Par2
Immunogen	E. coli - derived recombinant Mouse F2RL1 (Ser39-Gly73&Met214-Leu237&Ser350-Tyr399).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	P55086
Background	Proteinase-activated receptor 2 (F2RL1) is a ~44 kDa protein. Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. 1. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

Related Products: