Anti-Human NEK1 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Mouse
Target	Serine/threonine-protein kinase Nek1; 2.7.11.1; Never in mitosis A-related kinase 1; NimA-related protein kinase 1; Renal carcinoma antigen NY-REN-55; NEK1; KIAA1901
Immunogen	E. coli - derived recombinant Human NEK1 (Cys1177-Glu1258).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q96PY6
Background	Serine/threonine-protein kinase Nek1 is a ~142 kDa protein. Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly. 1. Chen, Y. et al. (2010) Biochemical and biophysical research communications 394, 798-803. PMID: 20230784 2. Thiel, C. et al. (2011) American journal of human genetics 88, 106-14. PMID: 21211617
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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