Anti-CYP26B1 Polyclonal Antibody
- Cat. No.：RB9THV995014
- Price：Negotiable
- Clicks：325
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse, Rat |
| Target | CYP26A2, CYP26B1, Cytochrome P450 26A2, Cytochrome P450 26B1, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, EC:1.14.13.-, P450RAI2, Retinoic acid-metabolizing cytochrome |
| Immunogen | E. coli - derived recombinant human CYP26B1 (Thr97-Val512). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping Condition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9NR63 |
| Observed Molecular Weight | 53 kDa |
| Background | Cytochrome P450 26B1 is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination. Involved in the convertion of atRA to all-trans-4-oxo-RA. 1. White, JA. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 6403-8. PMID: 10823918 2. Topletz, AR. et al. (2012) Biochemical pharmacology 83, 149-63. PMID: 22020119 3. Laue, K. et al. (2011) American journal of human genetics 89, 595-606. PMID: 22019272 |
| Note | For research use only |
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