Anti-Human KAT2B Polyclonal Antibody
- Cat. No.：RB9THA390024
- Price：Negotiable
- Clicks：490
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human |
| Target | EC:2.3.1.48, EC:2.3.1.57, Histone acetylase PCAF, Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, KAT2B, Lysine acetyltransferase 2B, P/CAF, P300/CBP-associated factor, PCAF, Spermidi |
| Immunogen | E. coli - derived recombinant Human KAT2B (Asn651-Lys818). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q92831 |
| Background | Histone acetyltransferase KAT2B is a ~93 kDa protein. Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. 1. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521 2. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905 3. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335 4. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180 5. Lin, R. et al. (2013) Molecular cell 51, 506-518. PMID: 23932781 6. Chen, S. et al. (2016) Nature communications 7, 10734. PMID: 26867678 7. Fournier, M. et al. (2016) Nature communications 7, 13227. PMID: 27796307 8. Ghosh, TK. et al. (2018) Journal of molecular and cellular cardiology 114, 185-198. PMID: 29174768 9. Zhang, W. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9855-60. PMID: 9707565 |
| Note | For research use only |
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