Anti-Human USP48 Polyclonal Antibody
- Cat. No.：RB9THB559024
- Price：Negotiable
- Clicks：424
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Rat, Mouse |
| Target | Deubiquitinating enzyme 48, EC:3.4.19.12, USP31, USP48, Ubiquitin carboxyl-terminal hydrolase 48, Ubiquitin thioesterase 48, Ubiquitin-specific peptidase 48, Ubiquitin-specific protease 48, Ubiquitin- |
| Immunogen | E. coli - derived recombinant Human USP48 (Gln423-Val559). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q86UV5 |
| Background | Ubiquitin carboxyl-terminal hydrolase 48 (USP48) is a ~119 kDa protein. Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. 1. Tzimas, C. et al. (2006) Cellular signalling 18, 83-92. PMID: 16214042 2. Bassani, S. et al. (2021) Human molecular genetics 30, 1785-1796. PMID: 34059922 3. Antao, AM. et al. (2021) International journal of molecular sciences 22. PMID: 34445214 4. Jantaree, P. et al. (2022) Cellular and molecular life sciences : CMLS 79, 461. PMID: 35913642 5. Sánchez-Bellver, L. et al. (2022) International journal of molecular sciences 23. PMID: 36293380 6. Ren, Y. et al. (2023) Cancer research 83, 1074-1093. PMID: 36607699 |
| Note | For research use only |
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