Anti-Human TACR2 Polyclonal Antibody
- Cat. No.：RB9THB728034
- Price：Negotiable
- Clicks：661
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | NK-2 receptor, NK-2R, NK2R, NKNAR, Neurokinin A receptor, SKR, Substance-K receptor, TAC2R, TACR2, Tachykinin receptor 2 |
| Immunogen | E. coli - derived recombinant Human TACR2 (Asn311-Asp362). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P21452 |
| Background | Substance-K receptor (TACR2) is a ~44 kDa protein. This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). Is also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). 1. Cyr, C. et al. (1991) Annals of the New York Academy of Sciences 632, 426-7. PMID: 1659297 2. Kris, RM. et al. (1991) Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2, 15-22. PMID: 1848773 3. Edgerton, MD. et al. (1994) FEBS letters 354, 195-9. PMID: 7957923 4. Sun, W. et al. (2022) Cell discovery 8, 72. PMID: 35882833 |
| Note | For research use only |
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