Anti-Human ERCC2 Polyclonal Antibody
- Cat. No.：RB9THB888014
- Price：Negotiable
- Clicks：473
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcr |
| Immunogen | E. coli - derived recombinant Human ERCC2 (Cys489-Leu760). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P18074 |
| Background | General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II. 1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769 2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672 3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713 4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882 5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626 6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696 7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107 |
| Note | For research use only |
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