Anti-Human ERCC3 Polyclonal Antibody
- Cat. No.：RB9THB951014
- Price：Negotiable
- Clicks：575
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Rat, Mouse |
| Target | BTF2 p89, Basic transcription factor 2 89 kDa subunit, DNA 3'-5' helicase/translocase XPB, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, EC:5.6.2.4, ERCC3, General t |
| Immunogen | E. coli - derived recombinant Human ERCC3 (Lys504-Glu725). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P19447 |
| Background | General transcription and DNA repair factor IIH helicase/translocase subunit XPB (ERCC3) is a ~89 kDa protein. ATP-dependent 3'-5' DNA helicase/translocase. Binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting that allows XPD/ERCC2 helicase to anchor. 1. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626 2. He, Y. et al. (2016) Nature 533, 359-65. PMID: 27193682 3. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107 4. Schaeffer, L. et al. (1993) Science (New York, N.Y.) 260, 58-63. PMID: 8465201 5. Hwang, JR. et al. (1996) The Journal of biological chemistry 271, 15898-904. PMID: 8663148 6. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882 7. van Vuuren, AJ. et al. (1994) The EMBO journal 13, 1645-53. PMID: 8157004 10. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769 |
| Note | For research use only |
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