Anti-Human SEPTIN2 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Rat, Mouse
Target	DIFF6, KIAA0158, NEDD-5, NEDD5, Neural precursor cell expressed developmentally down-regulated protein 5, SEPT2, SEPTIN2, Septin-2
Immunogen	E. coli - derived recombinant Human SEPTIN2 (Gly19-Val361).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q15019
Background	Septin-2 (SEPTIN2) is a ~41 kDa protein. Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. 1. Kuo, YC. et al. (2015) Journal of cell science 128, 923-34. PMID: 25588830
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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