Anti-Human PARD3 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Rat, Mouse
Target	ASIP, Atypical PKC isotype-specific-interacting protein, CTCL tumor antigen se2-5, PAR-3, PAR3, PAR3-alpha, PAR3A, PARD-3, PARD3, Partitioning defective 3 homolog
Immunogen	E. coli - derived recombinant Human PARD3 (Arg584-Lys686).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q8TEW0
Background	Partitioning defective 3 homolog (PARD3) is a ~151 kDa protein. Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. 1. Johansson, A. et al. (2000) Journal of cell science 113 ( Pt 18), 3267-75. PMID: 10954424 2. Chen, X. et al. (2017) Human mutation 38, 378-389. PMID: 27925688 3. Joberty, G. et al. (2000) Nature cell biology 2, 531-9. PMID: 10934474 4. Khazaei, MR. et al. (2009) The Journal of biological chemistry 284, 33571-9. PMID: 19812038
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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