Anti-Human PNPT1 Polyclonal Antibody
- Cat. No.：RB9THC241014
- Price：Negotiable
- Clicks：489
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human |
| Target | 3'-5' RNA exonuclease OLD35, EC:2.7.7.8, PNPASE, PNPT1, PNPase 1, PNPase old-35, Polynucleotide phosphorylase 1, Polynucleotide phosphorylase-like protein, Polyribonucleotide nucleotidyltransferase 1, |
| Immunogen | E. coli - derived recombinant Human PNPT1 (Gly43-Lys595). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q8TCS8 |
| Background | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) is a ~85 kDa protein. RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. 1. Pietras, Z. et al. (2018) Nature communications 9, 2558. PMID: 29967381 2. Kim, S. et al. (2024) Molecular cell 84, 2935-2948.e7. PMID: 39019044 |
| Note | For research use only |
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