Anti-Human RAPGEF1 Polyclonal Antibody
- Cat. No.：RB9THC394014
- Price：Negotiable
- Clicks：394
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | CRK SH3-binding GNRP, GRF2, Guanine nucleotide-releasing factor 2, Protein C3G, RAPGEF1, Rap guanine nucleotide exchange factor 1 |
| Immunogen | E. coli - derived recombinant Human RAPGEF1 (His842-Thr1077). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q13905 |
| Background | Rap guanine nucleotide exchange factor 1 (RAPGEF1) is a ~120 kDa protein. Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. 1. Sakakibara, A. et al. (2002) Journal of cell science 115, 4915-24. PMID: 12432078 |
| Note | For research use only |
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