| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:1.11.1.-, EC:2.5.1.-, EC:4.4.1.20, GST-3, Glutathione S-transferase 3, mitochondrial, Glutathione peroxidase MGST3, LTC4 synthase MGST3, MGST3 |
| Immunogen | E. coli - derived recombinant Human MGST3 (Ser30-Pro70). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O14880 |
| Background | Glutathione S-transferase 3, mitochondrial (MGST3) is a ~16 kDa protein. Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites. Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response. Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides. 1. Steinmetz-Späh, J. et al. (2022) Journal of lipid research 63, 100310. PMID: 36370807 2. Jakobsson, PJ. et al. (1997) The Journal of biological chemistry 272, 22934-9. PMID: 9278457 |
| Note | For research use only |