Anti-Human RRAD Polyclonal Antibody
- Cat. No.：RB9THD074014
- Price：Negotiable
- Clicks：200
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | GTP-binding protein RAD, RAD, RAD1, RRAD, Ras associated with diabetes |
| Immunogen | E. coli - derived recombinant Human RRAD (Val91-Leu308). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P55042 |
| Background | GTP-binding protein RAD (RRAD) is a ~33 kDa protein. May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. 1. Chang, L. et al. (2007) Circulation 116, 2976-2983. PMID: 18056528 |
| Note | For research use only |
Related Products: