Anti-Human CUL7 Polyclonal Antibody
- Cat. No.：RB9THD226014
- Price：Negotiable
- Clicks：209
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | CUL-7, CUL7, Cullin-7, KIAA0076 |
| Immunogen | E. coli - derived recombinant Human CUL7 (Met1-Ser317). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q14999 |
| Background | Cullin-7 (CUL7) is a ~191 kDa protein. Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53. However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1. 1. Dias, DC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16601-6. PMID: 12481031 2. Arai, T. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9855-60. PMID: 12904573 3. Litterman, N. et al. (2011) PLoS biology 9, e1001060. PMID: 21572988 4. Hanson, D. et al. (2011) American journal of human genetics 89, 148-53. PMID: 21737058 5. Yan, J. et al. (2014) Molecular cell 54, 791-804. PMID: 24793695 6. Hopf, LVM. et al. (2022) Nature structural & molecular biology 29, 854-862. PMID: 35982156 |
| Note | For research use only |
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