Anti-Human SPOUT1 Polyclonal Antibody
- Cat. No.：RB9THD297014
- Price：Negotiable
- Clicks：261
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human |
| Target | 28S rRNA (uridine-N(3))-methyltransferase, C9orf114, CENP-32, Centromere protein 32, EC:2.1.1.-, Kinetochore-associated protein, Methyltransferase C9orf114, Ribosomal RNA methyltransferase SPOUT1, SPO |
| Immunogen | E. coli - derived recombinant Human SPOUT1 (Thr74-Thr376). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q5T280 |
| Background | 28S rRNA (uridine-N(3))-methyltransferase (SPOUT1) is a ~42 kDa protein. S-adenosyl-L-methionine-dependent RNA methyltransferase. Specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase, ensuring proper spindle organization. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. 1. Chen, J. et al. (2024) Science advances 10, eadr1743. PMID: 39671501 2. Dharmadhikari, AV. et al. (2025) Nature communications 16, 1703. PMID: 39962046 3. Ohta, S. et al. (2010) Cell 142, 810-21. PMID: 20813266 4. Ohta, S. et al. (2015) Molecular biology of the cell 26, 1225-37. PMID: 25657325 5. Treiber, T. et al. (2017) Molecular cell 66, 270-284.e13. PMID: 28431233 |
| Note | For research use only |
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