Anti-Human FBXL3 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Mouse
Target	F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 3A, FBL3A, FBXL3, FBXL3A
Immunogen	E. coli - derived recombinant Human FBXL3 (Gly37-Trp428).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q9UKT7
Background	F-box/LRR-repeat protein 3 (FBXL3) is a ~48 kDa protein. Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. 1. Busino, L. et al. (2007) Science (New York, N.Y.) 316, 900-4. PMID: 17463251 2. Yoo, SH. et al. (2013) Cell 152, 1091-105. PMID: 23452855 3. Scott, DC. et al. (2016) Cell 166, 1198-1214.e24. PMID: 27565346
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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