Anti-Human TRIM31 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human
Target	C6orf13, E3 ubiquitin-protein ligase TRIM31, EC:2.3.2.27, RNF, TRIM31, Tripartite motif-containing protein 31
Immunogen	E. coli - derived recombinant Human TRIM31 (Met1-Gln145).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q9BZY9
Background	E3 ubiquitin-protein ligase TRIM31 is a ~48 kDa protein. E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth. 1. Sugiura, T. et al. (2008) Journal of cellular biochemistry 105, 1081-91. PMID: 18773414 2. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086 3. Liu, B. et al. (2017) Nature immunology 18, 214-224. PMID: 27992402
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

Related Products: