Anti-Human WDR24 Polyclonal Antibody
- Cat. No.：RB9THP377024
- Price：Negotiable
- Clicks：410
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | C16orf21, EC:2.3.2.27, GATOR2 complex protein WDR24, WD repeat-containing protein 24, WDR24 |
| Immunogen | E. coli - derived recombinant Human WDR24 (Met21-Ala331). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q96S15 |
| Background | GATOR2 complex protein WDR24 is a ~88 kDa protein. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 4. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 5. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 6. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 7. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624 |
| Note | For research use only |
Related Products: