Anti-Human HPS6 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human
Target	BLOC-2 complex member HPS6, HPS6, Hermansky-Pudlak syndrome 6 protein, Ru, Ruby-eye protein homolog
Immunogen	E. coli - derived recombinant Human HPS6 (Thr6-Gly387).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q86YV9
Background	BLOC-2 complex member HPS6 is a ~82 kDa protein. May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning. 1. Schreyer-Shafir, N. et al. (2006) Human mutation 27, 1158. PMID: 17041891 2. Li, K. et al. (2014) Journal of cell science 127, 4574-88. PMID: 25189619
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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