Anti-Mouse TRADD Polyclonal Antibody
- Cat. No.：RB9TMS785014
- Price：Negotiable
- Clicks：213
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse |
| Target | TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD, Tumor necrosis factor receptor type 1-associated DEATH domain protein |
| Immunogen | E. coli - derived recombinant Mouse TRADD (Trp11-Gln142). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q3U0V2 |
| Background | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a ~34 kDa protein. Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A. 1. Chio, II. et al. (2012) Nature cell biology 14, 625-33. PMID: 22561347 |
| Note | For research use only |
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