Anti-Human PLCD3 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Mouse, Human
Target	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, EC:3.1.4.11, KIAA1964, PLC-delta-3, PLCD3, Phosphoinositide phospholipase C-delta-3, Phospholipase C-delta-3
Immunogen	E. coli - derived recombinant Human PLCD3 (Pro46-Leu251).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q8N3E9
Background	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3) is a ~89 kDa protein. Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Regulates neurite outgrowth through the inhibition of RhoA/Rho kinase signaling. 1. Pawelczyk, T. et al. (1999) European journal of biochemistry 262, 291-8. PMID: 10336610
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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