Anti-Mouse NUMB Polyclonal Antibody
- Cat. No.：RB9TMW709014
- Price：Negotiable
- Clicks：260
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | C14orf41, NUMB, Protein S171, Protein numb homolog, h-Numb |
| Immunogen | E. coli - derived recombinant Mouse NUMB (Val16-Ala200). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q9QZS3 |
| Background | Protein numb homolog is a ~70 kDa protein. Regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. 1. Zhong, W. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 6844-9. PMID: 10841580 2. Petersen, PH. et al. (2002) Nature 419, 929-34. PMID: 12410312 3. Petersen, PH. et al. (2004) Nature neuroscience 7, 803-11. PMID: 15273690 4. Kuo, CT. et al. (2006) Cell 127, 1253-64. PMID: 17174898 |
| Note | For research use only |
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