Anti-Human NR3C1 Polyclonal Antibody
- Cat. No.：RB9THY450014
- Price：Negotiable
- Clicks：243
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse, Human, Rat |
| Target | GR, GRL, Glucocorticoid receptor, NR3C1, Nuclear receptor subfamily 3 group C member 1 |
| Immunogen | E. coli - derived recombinant Human NR3C1 (Ser555-Lys777). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P04150 |
| Background | Glucocorticoid receptor (NR3C1) is a ~85 kDa protein. Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. 1. Vitellius, G. et al. (2016) Human mutation 37, 794-803. PMID: 27120390 2. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846 3. Fadda, A. et al. (2017) Scientific reports 7, 41598. PMID: 28139699 4. Fryer, CJ. et al. (1998) Nature 393, 88-91. PMID: 9590696 5. Cho, H. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, E1540-9. PMID: 25775514 |
| Note | For research use only |
Related Products: