| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse |
| Target | 1-Cys PRX, 1-Cys peroxiredoxin, Acidic calcium-independent phospholipase A2, Antioxidant protein 2, Aop2, EC:1.11.1.27, EC:2.3.1.23, EC:3.1.1.4, Glutathione-dependent peroxiredoxin, LPC acyltransferas |
| Immunogen | E. coli - derived recombinant Mouse PRDX6 (Met1-Pro224). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O08709 |
| Background | Peroxiredoxin-6 (PRDX6) is a ~24 kDa protein. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Has phospholipase activity. Can either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. 1. Fisher, AB. et al. (2016) Journal of lipid research 57, 587-96. PMID: 26830860 |
| Note | For research use only |