| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse |
| Target | Annexin A1, Annexin Ac2-26, Annexin I, Annexin-1, Anx1, Anxa1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Lpc-1, Lpc1, Phospholipase A2 inhibitory protein, p35 |
| Immunogen | E. coli - derived recombinant Mouse ANXA1 (Ala2-Asn346). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P10107 |
| Background | Annexin A1 (ANXA1) is a ~38 kDa protein. Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells. Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells. 1. Hannon, R. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 253-5. PMID: 12475898 2. D'Acquisto, F. et al. (2007) European journal of immunology 37, 3131-42. PMID: 17948261 3. Patel, DM. et al. (2011) Journal of cell science 124, 578-88. PMID: 21245195 |
| Note | For research use only |