Anti-Mouse IL24 Polyclonal Antibody
- Cat. No.：RB9TMC472014
- Price：Negotiable
- Clicks：373
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse |
| Target | IL-24, IL-4-induced secreted protein, Il24, Interleukin-24, MDA-7, Mda7, Melanoma differentiation-associated gene 7 protein, Th2-specific cytokine FISP |
| Immunogen | E. coli - derived recombinant Mouse IL24 (Gln27-Leu181). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q925S4 |
| Background | Interleukin-24 (IL24) is a ~25 kDa protein. Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. 1. Wang, J. et al. (2020) Cell death & disease 11, 17. PMID: 31907348 2. Davidson, S. et al. (2022) Science immunology 7, eabi6763. PMID: 35148201 |
| Note | For research use only |
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