Anti-Mouse IL24 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Mouse
Target	IL-24, IL-4-induced secreted protein, Il24, Interleukin-24, MDA-7, Mda7, Melanoma differentiation-associated gene 7 protein, Th2-specific cytokine FISP
Immunogen	E. coli - derived recombinant Mouse IL24 (Gln27-Leu181).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	Q925S4
Background	Interleukin-24 (IL24) is a ~25 kDa protein. Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. 1. Wang, J. et al. (2020) Cell death & disease 11, 17. PMID: 31907348 2. Davidson, S. et al. (2022) Science immunology 7, eabi6763. PMID: 35148201
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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