Anti-Mouse LRRK2/Dardarin Polyclonal Antibody
- Cat. No.：RB9TMV789014
- Price：Negotiable
- Clicks：174
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Mouse |
| Target | EC:2.7.11.1, EC:3.6.5.-, Leucine-rich repeat serine/threonine-protein kinase 2, Lrrk2 |
| Immunogen | E. coli - derived recombinant Mouse LRRK2/Dardarin (Ile2151-Leu2500). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q5S006 |
| Background | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2/Dardarin) is a ~284 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A. 1. Steger, M. et al. (2016) eLife 5. PMID: 26824392 2. Chen, ZC. et al. (2017) Science signaling 10. PMID: 28720718 3. Steger, M. et al. (2017) eLife 6. PMID: 29125462 4. Purlyte, E. et al. (2018) The EMBO journal 37, 1-18. PMID: 29212815 5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148 6. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882 7. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220 |
| Note | For research use only |
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