| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse |
| Target | Agrin, Agrin C-terminal 110 kDa subunit, Agrin C-terminal 22 kDa fragment, Agrin C-terminal 90 kDa fragment, Agrin N-terminal 110 kDa subunit, Agrn, C22, C90 |
| Immunogen | E. coli - derived recombinant Mouse AGRN (Val1256-Gly1426). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | A2ASQ1 |
| Background | Agrin (AGRN) is a ~207 kDa protein. Depending on alternative splicing and post-translational modifications, it has a role in different processes, including neuromuscular junction formation and maintenance, and regulation of neurite outgrowth. Involved in the positive regulation of cartilage formation through alpha-dystroglycan binding and up-regulation of SOX9. 1. Burgess, RW. et al. (1999) Neuron 23, 33-44. PMID: 10402191 2. Burgess, RW. et al. (2000) The Journal of cell biology 151, 41-52. PMID: 11018052 3. Hoover, CL. et al. (2003) The Journal of cell biology 161, 923-32. PMID: 12796478 4. Ksiazek, I. et al. (2007) The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 7183-95. PMID: 17611272 5. Matsumoto-Miyai, K. et al. (2009) Cell 136, 1161-71. PMID: 19303856 6. Bütikofer, L. et al. (2011) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 4378-93. PMID: 21885656 7. Glass, DJ. et al. (1996) Cell 85, 513-23. PMID: 8653787 |
| Note | For research use only |
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