| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Rat, Mouse, Human |
| Target | Adgrb1, Adhesion G protein-coupled receptor B1, Bai1, Brain-specific angiogenesis inhibitor 1, Vasculostatin-120, Vasculostatin-40, Vstat-40, Vstat120 |
| Immunogen | E. coli - derived recombinant Mouse ADGRB1/BAI1 (Ser636-Thr940). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q3UHD1 |
| Background | Adhesion G protein-coupled receptor B1 (ADGRB1/BAI1) is a ~173 kDa protein. Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. 1. Park, D. et al. (2007) Nature 450, 430-4. PMID: 17960134 2. Das, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2136-41. PMID: 21245295 3. Billings, EA. et al. (2016) Science signaling 9, ra14. PMID: 26838550 4. Hochreiter-Hufford, AE. et al. (2013) Nature 497, 263-7. PMID: 23615608 5. Zhu, D. et al. (2015) The Journal of clinical investigation 125, 1497-508. PMID: 25751059 |
| Note | For research use only |