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Anti-MeV Non-structural protein V Polyclonal Antibody
- Cat. No.：RB9TVK815014
- Price：Negotiable
- Clicks：352
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Measles virus |
| Target | Non-structural protein V, P/V |
| Immunogen | E. coli - derived recombinant MeV Non-structural protein V (Met1-Gly231). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P0C774 |
| Background | Non-structural protein V is a ~32 kDa protein. Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Blocks the type I interferon signaling pathway by disrupting the RIG-I signaling pathway. 1. Takeuchi, K. et al. (2003) FEBS letters 545, 177-82. PMID: 12804771 2. Parisien, JP. et al. (2009) Journal of virology 83, 7252-60. PMID: 19403670 3. Ramachandran, A. et al. (2008) Journal of virology 82, 8330-8. PMID: 18579593 4. Chinnakannan, SK. et al. (2013) PloS one 8, e57063. PMID: 23431397 5. Davis, ME. et al. (2014) Cell host & microbe 16, 19-30. PMID: 25011105 |
| Note | For research use only |
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