Anti-HHV-5/HCMV UL83 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human cytomegalovirus
Target	65 kDa matrix phosphoprotein, 65 kDa phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83, pp65
Immunogen	E. coli - derived recombinant HHV-5/HCMV UL83 (Thr297-Tyr510).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	P06725
Background	65 kDa phosphoprotein (UL83) is a ~62 kDa protein. Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes. 1. Abate, DA. et al. (2004) Journal of virology 78, 10995-1006. PMID: 15452220 2. Biolatti, M. et al. (2018) Journal of virology 92. PMID: 29263269 3. Cox, JB. et al. (2025) Journal of virology 99, e0048125. PMID: 40243337 4. Cristea, IM. et al. (2010) Journal of virology 84, 7803-14. PMID: 20504932
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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