Anti-Human EPHB4 Polyclonal Antibody
- Cat. No.：RB9THX086014
- Price：Negotiable
- Clicks：185
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | EC:2.7.10.1, EPHB4, Ephrin type-B receptor 4, HTK, Hepatoma transmembrane kinase, MYK1, TYRO11, Tyrosine-protein kinase TYRO11 |
| Immunogen | E. coli - derived recombinant Human EPHB4 (Leu16-Ala539). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | P54760 |
| Background | Ephrin type-B receptor 4 (EPHB4) is a ~108 kDa protein. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. |
| Note | For research use only |
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