Anti-Human GPR37L1 Polyclonal Antibody
- Cat. No.：RB9THD416014
- Price：Negotiable
- Clicks：188
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | ETBR-LP-2, ETBRLP2, Endothelin B receptor-like protein 2, G-protein coupled receptor 37-like 1, GPR37L1 |
| Immunogen | E. coli - derived recombinant Human GPR37L1 (Ala26-Met134). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | O60883 |
| Background | G-protein coupled receptor 37-like 1 (GPR37L1) is a ~52 kDa protein. G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. 1. Coleman, JL. et al. (2016) Science signaling 9, ra36. PMID: 27072655 2. Meyer, RC. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 9529-34. PMID: 23690594 3. Giddens, MM. et al. (2017) Neurobiology of disease 106, 181-190. PMID: 28688853 |
| Note | For research use only |
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