Anti-Human PPP1R11 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Human, Rat
Target	E3 ubiquitin-protein ligase PPP1R11, EC:2.3.2.27, HCG V, HCGV, Hemochromatosis candidate gene V protein, PPP1R11, Protein phosphatase 1 regulatory subunit 11, Protein phosphatase inhibitor 3, TCTE5
Immunogen	E. coli - derived recombinant Human PPP1R11 (Arg26-His126).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	O60927
Background	E3 ubiquitin-protein ligase PPP1R11 is a ~13 kDa protein. Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. 1. McKelvey, AC. et al. (2016) eLife 5. PMID: 27805901 2. Zhang, J. et al. (1998) Biochemistry 37, 16728-34. PMID: 9843442
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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