Anti-Human CCR4 Polyclonal Antibody

Form	Liquid
Host Species	Rabbit
Clonality	Polyclonal
Isotype	IgG
Purification	Purified by antigen affinity column.
Endotoxin Level	Please contact with the lab for this information.
Applications	ELISA, IHC, WB
Species Reactivity	Homo sapiens (Human)
Target	C-C CKR-4, C-C chemokine receptor type 4, CC-CKR-4, CCR-4, CCR4, CD194, CMKBR4, K5-5
Immunogen	E. coli - derived recombinant Human CCR4 (Asn2-Glu39&Ser176-Ile206&Glu309-Leu360).
Storage Buffer	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Product Usage Information	ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
Accession Number	P51679
Background	C-C chemokine receptor type 4 (CCR4) is a ~41 kDa protein. High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Note	For research use only

For Research Use Only. Not for Diagnostic Procedures.

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