Anti-Human FIG4 Polyclonal Antibody
- Cat. No.：RB9THP232014
- Price：Negotiable
- Clicks：439
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human, Mouse |
| Target | EC:3.1.3.-, EC:3.1.3.16, EC:3.1.3.36, EC:3.1.3.86, FIG4, KIAA0274, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, Polyphosphoinositide phosphatase, SAC domain-containing protein 3, SAC3, Serine- |
| Immunogen | E. coli - derived recombinant Human FIG4 (Gly216-His665). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q92562 |
| Background | Polyphosphoinositide phosphatase (FIG4) is a ~103 kDa protein. Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. 1. Sbrissa, D. et al. (2007) The Journal of biological chemistry 282, 23878-91. PMID: 17556371 2. Lees, JA. et al. (2020) Molecular cell 80, 736-743.e4. PMID: 33098764 |
| Note | For research use only |
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