Anti-Human TRIM22 Polyclonal Antibody
- Cat. No.：RB9THC134014
- Price：Negotiable
- Clicks：308
Product Detail
Product Parameters
| Form | Liquid |
|---|---|
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification | Purified by antigen affinity column. |
| Endotoxin Level | Please contact with the lab for this information. |
| Applications | ELISA, IHC, WB |
| Species Reactivity | Human |
| Target | 50 kDa-stimulated trans-acting factor, E3 ubiquitin-protein ligase TRIM22, EC:2.3.2.27, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, RNF94, STAF50, Staf-50, TRIM22, Tripartite mo |
| Immunogen | E. coli - derived recombinant Human TRIM22 (Ser317-Ser498). |
| Storage Buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Product Usage Information | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| Accession Number | Q8IYM9 |
| Background | E3 ubiquitin-protein ligase TRIM22 is a ~56 kDa protein. Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity. Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A. Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation. Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter. 1. Yang, C. et al. (2016) Cellular & molecular immunology 13, 94-102. PMID: 25683609 2. Inoue, A. et al. (2022) Biochimica et biophysica acta. Molecular cell research 1869, 119318. PMID: 35777501 3. Zu, S. et al. (2022) Cell & bioscience 12, 139. PMID: 36042495 4. Turrini, F. et al. (2015) Retrovirology 12, 104. PMID: 26683615 5. Fei, X. et al. (2022) Molecular therapy oncolytics 26, 413-428. PMID: 36159777 |
| Note | For research use only |
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